Pre-irradiation at a Low Dose-rate Blunted p53 Response
نویسندگان
چکیده
منابع مشابه
Tumor suppressor p53 response is blunted by low-dose-rate radiation
INTRODUCTION Modulation of gene expression in response to ionizing radiation is of prime interest in the field of radiation biology. In most articles concerning biological responses to ionizing radiation, the findings of radiation-induced gene expression after irradiation at a lethal dose range (2-50 Gy) has been reported. Recently, the biological effect of low dose radiation on cellular respon...
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The link between high doses of radiation and thyroid cancer has been well established in various studies, as opposed to the effects of low doses. In this study, we investi-gated the effects of low-dose X-ray irradiation in a papillary thyroid carcinoma model with wild-type and mutated p53. A low dose of 62.5 mGy was enough to cause an upregulation of p16 and a decrease in the number of TPC-1 ce...
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ژورنال
عنوان ژورنال: Journal of Radiation Research
سال: 2002
ISSN: 0449-3060
DOI: 10.1269/jrr.43.1